Since the end of the 20^th century, nature-based health interventions (NBIs)–activities that engage people in nature-based experiences to improve health and well-being–have assumed increasing importance worldwide with special regard to countries with advanced economies and stressful lifestyles of people. NBIs refers to spending time in a natural environment to walk, run practice tai chi or meditation techniques in order to improve the metabolism and helps to achieve relaxation and physical recovery. In literature, some studies have highlighted that NBIs–e.g., nature-based education, wilderness therapy, leisure activity, horticulture therapy, forest bathing and therapy­–have positive impacts on the human immune system and mental health by reducing stress and anxiety. However, the natural sites where these activities are carried out must have some key features in order to optimize the positive effects of NBIs for human psycho-physical health. In this context, this study has conducted a systematic literature review in order to identify the key site and stand features for areas suitable for NBIs with special regard to forest bathing and therapy activities. To this end, the literature review conducted on the Scopus database (https://www.scopus.com) identified 70 peer-reviewed publications that were in-depth analysed. The results showed that the three most important site features are: accessibility, roughness and slope. A site to be suitable for “forest bathing” must be easily accessible, but at the same time not in the immediate vicinity of roads or parking lots, in order to avoid noise pollution disturbing the participants in the activity. Furthermore, the site must be characterized by low surface rockiness and a limited shrub and dead wood layer on the ground. Slope is another key variable as flat sites or those with a moderate slope (less than 10-15%) must be preferred. Another important aspect to improve the forest bathing activity is the presence of water elements (streams, waterfalls, small lakes) that can be important to stimulate the auditory, tactile and visual senses of the participants. Regarding the stand features, the results highlighted that the most important features are: tree species composition, age and stand structure. Tree species composition is the most important characteristic as it is closely linked to the quantity of Biogenic Volatile Organic Compounds-BVOC (d-limonene, a-Pinene e b-Pinene, b-Myrcene, Camfene) emitted by the tree species in the forest. Finally, some studies identified in literature have identified high forests (more than 60-70 years old) characterized by a diversified horizontal and vertical structure as ideal sites for NBIs.